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Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a specific type of dementia that mimics Alzheimer disease (AD) but is caused by TDP-43 protein deposits in the brain rather than beta-amyloid accumulation and mostly affects people older than 80 years, says a consensus working group convened by the US National Institute on Aging. LATE has “an expanding but […]

NEW YORK (Reuters Health) – Longitudinal plasma neurofilament light (NfL) levels are associated with neurodegeneration in Alzheimer disease, researchers report. “Plasma NfL is a noninvasive biomarker which may give information about the progressive neurodegeneration in patients with Alzheimer’s disease,” said Dr. Niklas Mattsson from Lund University, in Malmoe, Sweden. “This biomarker is one of several […]

NEW YORK (Reuters Health) – In children with epilepsy, recorded scalp spike ripples are better than spikes at predicting seizure risk, according to new findings. Spike ripples, or short bursts of high-frequency oscillations co-occurring with epileptiform discharges, are easier to detect than ripples alone and have greater pathological significance, researchers explain in Brain, online March […]

NEW YORK (Reuters Health) – Two rarely encountered genetic variants that already have roles in dementias also appear to be associated with Alzheimer’s disease (AD), according to a large genetic study. For example, as Dr. Lindsay A. Farrer told Reuters Health by email, “mutations in one of the genes (NOTCH3) had been previously implicated in […]